5 Treatment with quercetin decreased markers of oxidative stress and inflammation in plasma of patients with pulmonary sarcoidosis, another chronic lung inflammatory disease driven by oxidative stress. 3 Recent studies have also demonstrated amelioration of hyperglycaemia, reduction of blood pressure and improvement of cardiovascular health by inhibiting platelet aggregation in experimental models.Īccumulating epidemiological evidence suggests that quercetin-rich diets are associated with lower incidence of asthma 4 and reduce disease severity in subjects with COPD.
2 Quercetin supplemented diet also alleviates rhinovirus-induced lung inflammation in mice with COPD phenotype. We have demonstrated that oral treatment with a low dose of quercetin decreases inflammation, oxidative stress and matrix metalloproteinase production in a mouse model of COPD. Quercetin (3,3′,4′,5,7-pentahydroxyflavone) is a dietary flavonoid and has potent antioxidant and anti-inflammatory properties. 1 Therefore, a neutraceutical with potent antioxidant and anti-inflammatory properties and relatively few side effects could be an attractive treatment option for COPD. Although the exact cellular mechanisms underlying COPD pathogenesis are not completely understood, the consensus is that oxidative stress and inflammation induced by exposure to cigarette smoke or other environmental or occupational hazards are responsible for development of COPD. The current pharmacological therapies for COPD, such as corticosteroids and β2 agonists, may provide symptom relief, reduce the rate of exacerbations, hospitalisations and possibly mortality, but despite this, many patients still experience symptoms, exacerbations and disease progression. If you have questions about participating in research or current studies at UK, please contact us at call 85 or 85.Chronic obstructive pulmonary disease (COPD) is the major cause of mortality and morbidity in the USA and growing cause of chronic disease globally. Learn more about participating in research studies. Join ResearchMatch, which connects potential volunteers with researchers nationwide and in Kentucky Join Wellness, Health & You, which seeks to learn more about factors affecting about Kentuckians' health and connects you with research opportunities that may interest you
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